Reaction Details
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3-phosphoinositide-dependent protein kinase 1 [50-359]
Ligand
BDBM199118
Substrate
n/a
Meas. Tech.
Isothermal titration calorimetry
pH
7.4±n/a
Kd
20000±0 nM
Comments
extracted
Citation
Schulze, JO; Saladino, G; Busschots, K; Neimanis, S; Süß, E; Odadzic, D; Zeuzem, S; Hindie, V; Herbrand, AK; Lisa, MN; Alzari, PM; Gervasio, FL; Biondi, RM Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol 23:1193-1205 (2016) [PubMed] Article More Info.:
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [50-359]
Synonyms:
3-Phosphoinositide dependent protein kinase-1 | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
n/a
Mol. Mass.:
35373.34
Organism:
Homo sapiens (Human)
Description:
O15530[50-359]
Residue:
310
Sequence:
AMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT
Inhibitor
Name:
BDBM199118
Synonyms:
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | Adenosine
Type:
Small organic molecule
Emp. Form.:
C10H13N5O4
Mol. Mass.:
267.2413
SMILES:
Nc1ncnc2n(cnc12)C1OC(CO)C(O)C1O
Structure:
