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Target
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A]
Ligand
BDBM199181
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
597±0.0 nM
Citation
 Venkannagari, H; Verheugd, P; Koivunen, J; Haikarainen, T; Obaji, E; Ashok, Y; Narwal, M; Pihlajaniemi, T; Lüscher, B; Lehtiö, L Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol 23:1251-1260 (2016) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A]
Synonyms:
Human diphtheria toxin-like ADP-ribosyltransferase (R931A) (ARTD10 or PARP10(R931A) | PAR10_HUMAN | PARP10
Type:
n/a
Mol. Mass.:
23334.14
Organism:
Homo sapiens (Human)
Description:
Q53GL7[809-1017,R931A]
Residue:
209
Sequence:
AGQTLKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDAYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSG
  
Inhibitor
Name:
BDBM199181
Synonyms:
4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Structure:
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