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Target
Poly [ADP-ribose] polymerase tankyrase-1 [1112-1317]
Ligand
BDBM200007
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
9080±760 nM
Comments
extracted
Citation
 Cheung, AK; Chin, DN; Fan, J; Shultz, MD; Tomlinson, RC 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors US Patent  US9227982 Publication Date 1/5/2016 
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-1 [1112-1317]
Synonyms:
PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase 1 PARP catalytic domain (TNKS1P)
Type:
n/a
Mol. Mass.:
23585.97
Organism:
Homo sapiens (Human)
Description:
O95271[1112-1317]
Residue:
206
Sequence:
APEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPS
  
Inhibitor
Name:
BDBM200007
Synonyms:
US9227982, 25
Type:
Small organic molecule
Emp. Form.:
C23H25N3O4S
Mol. Mass.:
439.527
SMILES:
C[C@@H](N(Cc1nc2CCOCc2c(=O)[nH]1)S(=O)(=O)Cc1ccccc1)c1ccccc1 |r|
Structure:
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