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Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM200563
Substrate
n/a
Meas. Tech.
Recombinant Receptor Functional Assay B
Temperature
310.15±n/a K
IC50
380±n/a nM
Comments
extracted
Citation
 Bell, IM; Fraley, M; Biftu, T; Zhu, C; Nair, A Pyridine CGRP receptor antagonists US Patent  US9227973 Publication Date 1/5/2016 
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
  
Inhibitor
Name:
BDBM200563
Synonyms:
US9227973, 7A
Type:
Small organic molecule
Emp. Form.:
C31H25F2N5O2
Mol. Mass.:
537.5593
SMILES:
Fc1cccc([C@H]2CC[C@H](NC(=O)c3cnc4C[C@]5(Cc4c3)C(=O)Nc3ncccc53)c3ncccc3C2)c1F |r|
Structure:
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