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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM203583
Substrate
n/a
Meas. Tech.
IMAP technology (Molecular Devices)
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
5±n/a nM
Comments
extracted
Citation
 Seganish, WM; Brumfield, SN; Lim, J; Matasi, JJ; McElroy, WT; Tulshian, DB; Lavey, BJ; Altman, MD; Gibeau, CR; Lampe, JW; Methot, J; Zhu, L Aminopyrimidinones as interleukin receptor-associated kinase inhibitors US Patent  US9221809 Publication Date 12/29/2015 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM203583
Synonyms:
US9221809, 141
Type:
Small organic molecule
Emp. Form.:
C26H30N8O2S
Mol. Mass.:
518.634
SMILES:
COc1ccc(nc1)N1CCN(CC1)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1 |r|
Structure:
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