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Target
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Ligand
BDBM204845
Substrate
n/a
Meas. Tech.
LanthaScreen Kinase Assay
pH
7.5±n/a
IC50
30±n/a nM
Comments
extracted
Citation
 Takeuchi, J; Ikura, M; Higashino, M; Iwahashi, M; Hashimura, K Trk-inhibiting compound US Patent  US9242977 Publication Date 1/26/2016 
Target
Name:
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Synonyms:
High affinity nerve growth factor receptor (TrkAI) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A (Trk-A)
Type:
Enzyme
Mol. Mass.:
86881.47
Organism:
Homo sapiens (Human)
Description:
P04629-2
Residue:
790
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM204845
Synonyms:
US9242977, 72-7
Type:
Small organic molecule
Emp. Form.:
C30H26N8O3S
Mol. Mass.:
578.644
SMILES:
O=C(Nc1cc(nn1-c1ccccc1)C1CC1)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1
Structure:
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