Reaction Details Report a problem with these data
Target
Bcl-2-like protein 1 [1-209]
Ligand
BDBM156403
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
IC50
0.5±n/a nM
Comments
extracted
Citation
 Diebold, RB; Gero, TW; Grover, P; Huang, S; Ioannidis, S; Ogoe, CA; Saeh, JC Chemical compounds US Patent  US9248140 Publication Date 2/2/2016 
Target
Name:
Bcl-2-like protein 1 [1-209]
Synonyms:
Apoptosis regulator Bcl-XL | B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX
Type:
Protein
Mol. Mass.:
23354.38
Organism:
Homo sapiens (Human)
Description:
C-terminal 6XHIS tagged Bcl-XL (aa 1-209)
Residue:
209
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER
  
Inhibitor
Name:
BDBM156403
Synonyms:
US9018381, 26 | US9248140, 26
Type:
Small organic molecule
Emp. Form.:
C51H59ClF3N5O7S3
Mol. Mass.:
1042.687
SMILES:
CCN(CC)CC1CN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CCO1 |r|
Structure:
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