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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM206317
Substrate
n/a
Meas. Tech.
In vitro MAO-A/B Inhibition Assay
IC50
7.74e+4± 3.7e+3 nM
Citation
 Jia, WZ; Cheng, F; Zhang, YJ; Ge, JY; Yao, SQ; Zhu, Q Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry. Chem Biol Drug Des 89:141-151 (2017) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM206317
Synonyms:
2-phenyl-6-((5-((p-tolylamino)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4H-chromen-4-one (Az1k18)
Type:
Small organic molecule
Emp. Form.:
C26H22N4O2
Mol. Mass.:
422.4785
SMILES:
Cc1ccc(NCc2cnnn2Cc2ccc3oc(cc(=O)c3c2)-c2ccccc2)cc1
Structure:
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