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Target
Delta-type opioid receptor
Ligand
BDBM50105085
Substrate
n/a
Meas. Tech.
Binding of PEG-Nalbuphine assays
Ki
318.85±0.0 nM
Citation
 Riggs-Sauthier, J; Deng, B; Riley, TA Oligomer-opioid agonist conjugates US Patent  US9233167 Publication Date 1/12/2016 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50105085
Synonyms:
17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol | CHEMBL895 | N-cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol | NALBUPHINE | US10231963, Table B.1 | US10512644, Compound Nalbuphine | US11534436, Compound Table B.1 | US9233167, Nalbuphine | US9656961, Example 00118 | USRE49340, Rank 9
Type:
Small organic molecule
Emp. Form.:
C21H27NO4
Mol. Mass.:
357.4434
SMILES:
O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45 |r|
Structure:
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