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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM209528
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent  US9271969 Publication Date 3/1/2016 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM209528
Synonyms:
US9271969, 16
Type:
Small organic molecule
Emp. Form.:
C28H26ClN3O3
Mol. Mass.:
487.977
SMILES:
OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1cccc(Cl)c1 |r,wD:4.3,(9.68,-5.75,;8.34,-4.98,;8.34,-3.44,;7.01,-5.75,;5.67,-4.98,;5.67,-3.44,;4.34,-2.67,;3.01,-3.44,;3.01,-4.98,;4.34,-5.75,;1.67,-2.67,;.34,-3.44,;-.99,-2.67,;-.99,-1.13,;.34,-.36,;1.67,-1.13,;-2.33,-.36,;-2.33,1.18,;-3.66,1.95,;-5,1.18,;-6.46,1.66,;-7.37,.41,;-6.46,-.83,;-5,-.36,;-3.66,-1.13,;-8.91,.41,;-9.68,-.92,;-9.68,1.75,;-8.91,3.08,;-9.68,4.41,;-8.91,5.75,;-7.37,5.75,;-6.6,4.41,;-5.06,4.41,;-7.37,3.08,)|
Structure:
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