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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM209569
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
<10±n/a nM
Comments
extracted
Citation
 Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent  US9271969 Publication Date 3/1/2016 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM209569
Synonyms:
US9271969, 57
Type:
Small organic molecule
Emp. Form.:
C28H29N3O4S
Mol. Mass.:
503.613
SMILES:
COc1ccc(CNC(=O)c2cn3cc(sc3n2)-c2ccc(cc2)C2CC[C@H](CC(O)=O)CC2)cc1 |r,wD:27.30,(-12.76,4.67,;-11.22,4.67,;-10.45,3.33,;-8.91,3.33,;-8.14,2,;-8.91,.67,;-8.14,-.67,;-8.91,-2,;-8.14,-3.33,;-8.91,-4.67,;-6.6,-3.33,;-5.7,-4.58,;-4.24,-4.1,;-2.77,-4.58,;-1.87,-3.33,;-2.77,-2.09,;-4.24,-2.56,;-5.7,-2.09,;-.33,-3.33,;.44,-2,;1.98,-2,;2.75,-3.33,;1.98,-4.67,;.44,-4.67,;4.29,-3.33,;5.06,-2,;6.6,-2,;7.37,-3.33,;8.91,-3.33,;9.68,-2,;11.22,-2,;8.91,-.67,;6.6,-4.67,;5.06,-4.67,;-10.45,.67,;-11.22,2,)|
Structure:
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