Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM209638
Substrate
n/a
Meas. Tech.
Spectrophotometrical Assay
pH
7.5±n/a
IC50
371000±13000 nM
Comments
extracted
Citation
 Kantrowitz, ERHeng, S Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof US Patent  US9273021 Publication Date 3/1/2016 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM209638
Synonyms:
US9273021, Usnic Acid
Type:
Small organic molecule
Emp. Form.:
C18H16O7
Mol. Mass.:
344.3154
SMILES:
CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)C2(C)C1=O |c:3,t:6|
Structure:
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