Reaction Details
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D-3-phosphoglycerate dehydrogenase [3-314]
Ligand
BDBM209925
Substrate
n/a
Meas. Tech.
PHGDH Enzyme Assay
pH
7.1±n/a
IC50
3.50e+4± 6.9e+3 nM
Comments
extracted
Citation
Wang, Q; Liberti, MV; Liu, P; Deng, X; Liu, Y; Locasale, JW; Lai, L Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol 24:55-65 (2017) [PubMed] Article More Info.:
Target
Name:
D-3-phosphoglycerate dehydrogenase [3-314]
Synonyms:
PGDH3 | PHGDH | Phosphoglycerate dehydrogenase N-terminal fragment (PHGDH fragment) | SERA_HUMAN
Type:
Protein
Mol. Mass.:
33421.71
Organism:
Homo sapiens (Human)
Description:
PHGDH N-terminal fragment (3-314 aa)
Residue:
312
Sequence:
FANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTG
Inhibitor
Name:
BDBM209925
Synonyms:
PKUMDL-WQ-2201
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O3S
Mol. Mass.:
351.808
SMILES:
CCNC(=S)N\N=C/c1ccc(o1)-c1ccc(C(O)=O)c(Cl)c1
Structure:
