Reaction Details Report a problem with these data
Target
Dihydrofolate reductase type 1 from Tn4003
Ligand
BDBM210927
Substrate
n/a
Meas. Tech.
DHFR Inhibition Assay
IC50
3.6e+2± 2e+1 nM
Citation
 Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol 23:1458-1467 (2016) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase type 1 from Tn4003
Synonyms:
DYRA_STAAU | Dihydrofolate reductase (DfrA) | dfrA
Type:
Protein
Mol. Mass.:
18461.80
Organism:
Staphylococcus aureus
Description:
P13955
Residue:
161
Sequence:
MTLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFNSIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRRKGK
  
Inhibitor
Name:
BDBM210927
Synonyms:
UCP1039
Type:
Small organic molecule
Emp. Form.:
C22H23N5O2
Mol. Mass.:
389.4503
SMILES:
CCc1nc(N)nc(N)c1C#CCc1cc(OC)c(OC)c(c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: