Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431083
Substrate
n/a
Meas. Tech.
In Vitro DAAO Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
11±n/a nM
Comments
extracted
Citation
Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinone compounds and their use as DAAO inhibitors US Patent US9290456 Publication Date 3/22/2016
More Info.:
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Inhibitor
Name:
BDBM50431083
Synonyms:
CHEMBL2338803 | US10202399, Example 24 | US10463663, Example 8 | US11129828, Example 8 | US9212147, 24 | US9290456, 8 | US9931340, Example 8
Type:
Small organic molecule
Emp. Form.:
C12H10F2N2O2
Mol. Mass.:
252.2168
SMILES:
Oc1cc(CCc2cc(F)cc(F)c2)n[nH]c1=O