Reaction Details Report a problem with these data
Target
Taste receptor type 2 member 14
Ligand
BDBM211100
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assays
IC50
1619.00±n/a nM
Citation
 Karanewsky, DS; Fotsing, JR; Tachdjian, C; Arellano, M Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof US Patent  US9247759 Publication Date 2/2/2016 
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
  
Inhibitor
Name:
BDBM211100
Synonyms:
US9247759, 5-21
Type:
Small organic molecule
Emp. Form.:
C23H28N2O5S
Mol. Mass.:
444.544
SMILES:
CC(=O)Nc1ccc(cc1)S(=O)(=O)N(CC1CCC(CC1)C(O)=O)Cc1ccccc1 |(-6.38,-.84,;-6.38,.7,;-7.71,1.47,;-5.04,1.47,;-3.71,.7,;-2.38,1.47,;-1.04,.7,;-1.04,-.84,;-2.38,-1.61,;-3.71,-.84,;.29,-1.61,;-.48,-2.94,;1.06,-2.94,;1.62,-.84,;1.62,.7,;2.96,1.47,;4.45,1.07,;5.53,2.16,;5.14,3.65,;3.65,4.05,;2.56,2.96,;6.22,4.74,;7.71,4.34,;5.83,6.23,;2.96,-1.61,;2.96,-3.15,;1.62,-3.92,;1.62,-5.46,;2.96,-6.23,;4.29,-5.46,;4.29,-3.92,)|
Structure:
Search PDB for entries with ligand similarity: