Reaction Details Report a problem with these data
Target
Taste receptor type 2 member 14
Ligand
BDBM211127
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assays
IC50
342.00±n/a nM
Citation
Karanewsky, DS; Fotsing, JR; Tachdjian, C; Arellano, M Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof US Patent US9247759 Publication Date 2/2/2016
More Info.:
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
Inhibitor
Name:
BDBM211127
Synonyms:
US9247759, 5-51
Type:
Small organic molecule
Emp. Form.:
C19H22FNO4S2
Mol. Mass.:
411.511
SMILES:
OC(=O)C1CCC(CN(Cc2ccc(F)cc2)S(=O)(=O)c2cccs2)CC1 |(5.44,5.27,;3.95,5.67,;3.55,7.16,;2.86,4.58,;3.26,3.09,;2.17,2,;.69,2.4,;-.4,1.31,;-.4,-.23,;.93,-1,;.93,-2.54,;2.26,-3.31,;2.26,-4.85,;.93,-5.62,;.93,-7.16,;-.4,-4.85,;-.4,-3.31,;-1.74,-1,;-2.51,-2.33,;-.97,-2.33,;-3.07,-.23,;-4.54,-.7,;-5.44,.54,;-4.54,1.79,;-3.07,1.31,;.29,3.89,;1.38,4.98,)|