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Target
Tyrosine-protein kinase SYK [2-635]
Ligand
BDBM211958
Substrate
n/a
Meas. Tech.
Chip Based Microfluidic Mobility Shift Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
4.6±n/a nM
Comments
extracted
Citation
 Smith, AB; Thoma, G; Van Eis, M Monocyclic heteroaryl cycloalkyldiamine derivatives US Patent  US9290481 Publication Date 3/22/2016 
Target
Name:
Tyrosine-protein kinase SYK [2-635]
Synonyms:
KSYK_HUMAN | SYK | Tyrosine-protein kinase SYK | Tyrosine-protein kinase SYK (SYK)
Type:
Protein
Mol. Mass.:
71948.80
Organism:
Homo sapiens (Human)
Description:
Human Syk (2-635 aa) (UniProtKB: P43405)
Residue:
634
Sequence:
ASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM211958
Synonyms:
US9290481, 2.6
Type:
Small organic molecule
Emp. Form.:
C18H21FN8O
Mol. Mass.:
384.4107
SMILES:
N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc(F)cc3cc[nH]c23)n1 |r|
Structure:
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