Reaction Details Report a problem with these data
Target
Isoform 5 of Histone deacetylase 7 (5) 18-991]
Ligand
BDBM50207561
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
8±n/a
IC50
354±0.0 nM
Comments
extracted
Citation
 Shakespear, MR; Hohenhaus, DM; Kelly, GM; Kamal, NA; Gupta, P; Labzin, LI; Schroder, K; Garceau, V; Barbero, S; Iyer, A; Hume, DA; Reid, RC; Irvine, KM; Fairlie, DP; Sweet, MJ Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages. J Biol Chem 288:25362-74 (2013) [PubMed]  Article 
Target
Name:
Isoform 5 of Histone deacetylase 7 (5) 18-991]
Synonyms:
HDAC7 | HDAC7A | HDAC7_HUMAN | Histone deacetylase 7 (5) [518-991] | Histone deacetylase 7 (HDAC7)
Type:
Protein
Mol. Mass.:
51059.65
Organism:
Homo sapiens (Human)
Description:
Human HDAC7 truncation (518-991 aa)
Residue:
474
Sequence:
RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
  
Inhibitor
Name:
BDBM50207561
Synonyms:
CHEMBL396097 | Class IIa HDAC inhibitor, Compound 6 | N-hydroxy-2,2-diphenylacetamide
Type:
Small organic molecule
Emp. Form.:
C14H13NO2
Mol. Mass.:
227.2585
SMILES:
ONC(=O)C(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: