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Target
Acetyl-CoA carboxylase 2 [129-967]
Ligand
BDBM212754
Substrate
n/a
Meas. Tech.
Spectrophotometric 384 Well Assay
pH
7.5±n/a
IC50
789±n/a nM
Comments
extracted
Citation
 Heine, N; Fleck, M; Nosse, B; Roth, GJ Pyrrolidine derivatives, pharmaceutical compositions and uses thereof US Patent  US9278954 Publication Date 3/8/2016 
Target
Name:
Acetyl-CoA carboxylase 2 [129-967]
Synonyms:
ACACB | ACACB_HUMAN | ACC2 | ACCB | Acetyl-CoA carboxylase 2 (ACC2)
Type:
Enzyme
Mol. Mass.:
92599.28
Organism:
Homo sapiens (Human)
Description:
O00763 lacks the 128 amino acids at the N-terminus
Residue:
839
Sequence:
DTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPS
  
Inhibitor
Name:
BDBM212754
Synonyms:
US9278954, 6.8 isomer 1 | US9278954, 6.8 isomer 2 | US9278954, 7.34
Type:
Small organic molecule
Emp. Form.:
C24H32N2O3
Mol. Mass.:
396.5225
SMILES:
CCCOc1ccc(cc1)N1CC[C@H](C1)Oc1ccc(cc1)C(C)C(=O)NCC |r|
Structure:
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