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Target
Vitamin K epoxide reductase complex subunit 1-like protein 1
Ligand
BDBM50343352
Substrate
n/a
Meas. Tech.
VKOR Activity Assay
pH
7.4±n/a
Temperature
310.15±n/a K
Ki
3.26e+4± 1.9e+3 nM
Comments
extracted
Citation
 Hammed, A; Matagrin, B; Spohn, G; Prouillac, C; Benoit, E; Lattard, V VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. J Biol Chem 288:28733-42 (2013) [PubMed]  Article 
Target
Name:
Vitamin K epoxide reductase complex subunit 1-like protein 1
Synonyms:
VKORC1-like 1 (rVKORC1L1) | VKORL_RAT | Vkorc1l1
Type:
Enzyme
Mol. Mass.:
19785.33
Organism:
Rattus norvegicus (Rat)
Description:
Q6TEK3
Residue:
176
Sequence:
MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALVLMTSSIVSVVGSLYLAYILYFVLKEFCIICVTTYVLNFLLLIINYKRLVYLNEAWKRQLQPKED
  
Inhibitor
Name:
BDBM50343352
Synonyms:
2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one | 4-(4-hydroxy-2-oxo-2H-3-chromenyl)-4-phenyl-2-butanone | 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one | 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one | CHEMBL1464 | Coumadin | Jantoven | Warfarin4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one | wafarin | warfarin | warfarine
Type:
Small organic molecule
Emp. Form.:
C19H16O4
Mol. Mass.:
308.3279
SMILES:
CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
Structure:
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