Reaction Details
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Macrophage-stimulating protein receptor [983-1400,G1195S]
Ligand
BDBM213708
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
4.3±0.0 nM
Comments
extracted
Citation
Staehle, W; Schadt, O; Knuehl, C; Friese-Hamim, M; Huck, BR; Goutopoulos, A; Brugger, N Pyrido-pyrimidine derivatives US Patent US9283225 Publication Date 3/15/2016 More Info.:
Target
Name:
Macrophage-stimulating protein receptor [983-1400,G1195S]
Synonyms:
MST1R | Macrophage-stimulating protein receptor (RON) | PTK8 | RON | RON_HUMAN
Type:
Protein
Mol. Mass.:
47287.22
Organism:
Homo sapiens (Human)
Description:
MST1R (RON) recombinant human protein (Life Technologies, 983-1400 aa)
Residue:
418
Sequence:
RRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT
Inhibitor
Name:
BDBM213708
Synonyms:
US9283225, A1
Type:
Small organic molecule
Emp. Form.:
C24H16F4N6O3
Mol. Mass.:
512.4159
SMILES:
Fc1cc(NC(=O)c2cnn(c2C(F)(F)F)-c2ccccc2)ccc1Oc1ccnc2NC(=O)NCc12
Structure:
