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Target
Dual specificity protein kinase TTK [2-857]
Ligand
BDBM213745
Substrate
n/a
Meas. Tech.
MPS1 Kinase Activity Assay
pH
7.5±n/a
IC50
<2e+2±n/a nM
Comments
extracted
Citation
 Casuscelli, F; Brasca, MG; Caldarelli, M; Cervi, G; Disingrini, T; Quartieri, F Pyrazolyl-pyrimidine derivatives as kinase inhibitors US Patent  US9284298 Publication Date 3/15/2016 
Target
Name:
Dual specificity protein kinase TTK [2-857]
Synonyms:
Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | TTK | TTK_HUMAN
Type:
Enzyme
Mol. Mass.:
96955.60
Organism:
Homo sapiens (Human)
Description:
residues 2-857 of the full length sequence P33981
Residue:
856
Sequence:
ESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK
  
Inhibitor
Name:
BDBM213745
Synonyms:
US9284298, 13
Type:
Small organic molecule
Emp. Form.:
C31H38N8O3
Mol. Mass.:
570.6852
SMILES:
CCc1cccc(CC)c1NC(=O)c1cc([nH]n1)-c1ccnc(Nc2ccc(cc2OC)N2CCN(CCO)CC2)n1
Structure:
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