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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM213747
Substrate
n/a
Meas. Tech.
PIM1 Activity Assay
pH
3±n/a
Temperature
277.15±n/a K
IC50
<1.0e+4±n/a nM
Comments
extracted
Citation
 Casuscelli, F; Brasca, MG; Caldarelli, M; Cervi, G; Disingrini, T; Quartieri, F Pyrazolyl-pyrimidine derivatives as kinase inhibitors US Patent  US9284298 Publication Date 3/15/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM213747
Synonyms:
US9284298, 21
Type:
Small organic molecule
Emp. Form.:
C14H18N6OS
Mol. Mass.:
318.397
SMILES:
CSc1nccc(n1)-c1cc(nn1C1CCNCC1)C(N)=O
Structure:
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