Reaction Details Report a problem with these data
Target
Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686]
Ligand
BDBM32102
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Temperature
298.15±n/a K
Ki
171250±130 nM
Comments
extracted
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9284299 Publication Date 3/15/2016 
Target
Name:
Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686]
Synonyms:
Beta-catenin/APC-R3
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Component 2
Name:
Adenomatous polyposis coli protein [1477-1519]
Synonyms:
APC | APC_HUMAN | Adenomatous polyposis coli protein (APC-R3) | DP2.5
Type:
Enzyme
Mol. Mass.:
4662.54
Organism:
Homo sapiens (Human)
Description:
Human APC-R3 truncation (1477-1519 aa)
Residue:
43
Sequence:
QRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKD
  
Inhibitor
Name:
BDBM32102
Synonyms:
1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000087831 | SMR000024051 | US9284299, PKF118-310 | US9738628, Compound PKF118-310 | cid_66541
Type:
Small organic molecule
Emp. Form.:
C7H7N5O2
Mol. Mass.:
193.1628
SMILES:
Cn1ncnc2c1nc(=O)n(C)c2=O
Structure:
Search PDB for entries with ligand similarity: