Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM217343
Substrate
BDBM217351
Meas. Tech.
LTA4H Enzyme Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.1±n/a nM
Comments
extracted
Citation
Abeywardane, A; Broadwater, J; Takahashi, H Inhibitors of leukotriene production US Patent US9303018 Publication Date 4/5/2016
More Info.:
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
Inhibitor
Name:
BDBM217343
Synonyms:
US9303018, 16
Type:
Small organic molecule
Emp. Form.:
C25H26N6O2
Mol. Mass.:
442.5129
SMILES:
CN(CC1CN(C1)C(C)=O)Cc1cnc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1