Reaction Details
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Serine/threonine-protein phosphatase 5
Ligand
BDBM217375
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Kd
>1.0e+4±n/a nM
Comments
extracted
Citation
Connarn, JN; Assimon, VA; Reed, RA; Tse, E; Southworth, DR; Zuiderweg, ER; Gestwicki, JE; Sun, D The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. J Biol Chem 289:2908-17 (2014) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 5
Synonyms:
PP-T | PP5 | PPP5 | PPP5C | PPP5_HUMAN | PPT | Protein phosphatase 5 (PP5) | Protein phosphatase T | Serine/threonine-protein phosphatase 5
Type:
Enzyme
Mol. Mass.:
56875.49
Organism:
Homo sapiens (Human)
Description:
P53041
Residue:
499
Sequence:
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
Inhibitor
Name:
BDBM217375
Synonyms:
DVEEM
Type:
Small organic molecule
Emp. Form.:
C24H39N5O12S
Mol. Mass.:
621.658
SMILES:
CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(O)=O |r|
Structure:
