Reaction Details Report a problem with these data
Target
S-methyl-5'-thioinosine phosphorylase
Ligand
BDBM50247151
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
0.34±n/a nM
Comments
extracted
Citation
 Schramm, VL; Clinch, K; Tyler, PC; Evans, GB; Furneaux, RH Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase US Patent  US9290501 Publication Date 3/22/2016 
Target
Name:
S-methyl-5'-thioinosine phosphorylase
Synonyms:
MTIP_PSEAE | S-methyl-5'-thioinosine phosphorylase (MTIP)
Type:
Enzyme
Mol. Mass.:
26266.70
Organism:
Pseudomonas aeruginosa
Description:
Q9HZK1
Residue:
245
Sequence:
MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLAG
  
Inhibitor
Name:
BDBM50247151
Synonyms:
7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL514795 | US9290501, (C)
Type:
Small organic molecule
Emp. Form.:
C13H18N4O2S
Mol. Mass.:
294.373
SMILES:
CSC[C@H]1CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O |r|
Structure:
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