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Target
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2
Ligand
BDBM50004108
Substrate
n/a
Meas. Tech.
[3H]Epibatidine Binding Assay
pH
7.4000±n/a
Temperature
298.1500±n/a K
Ki
1.5±0.3 nM
Comments
extracted
Citation
 Carroll, FI; Ondachi, PW Nicotinic receptor compounds US Patent  US9284322 Publication Date 3/15/2016 
Target
Name:
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2
Synonyms:
nAChR alpha4 beta2 subtype | Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/beta-2
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)
Synonyms:
Neuronal acetylcholine receptor subunit alpha 4 subtype | ACHA4_RAT | Chrna4 | Acra4 | Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2) | Neuronal acetylcholine receptor subunit alpha-4 beta 2
Type:
Enzyme
Mol. Mass.:
70323.63
Organism:
Rat
Description:
P09483-2
Residue:
631
Sequence:
MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
  
Component 2
Name:
Neuronal acetylcholine receptor subunit beta-2
Synonyms:
Neuronal acetylcholine receptor non-alpha-1 chain | N-alpha 1 | ACHB2_RAT | Chrnb2 | Acrb2
Type:
Enzyme
Mol. Mass.:
56910.32
Organism:
Rat
Description:
P12390
Residue:
500
Sequence:
MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPLFQNYTATTFLHPDHSAPSSK
  
Inhibitor
Name:
BDBM50004108
Synonyms:
(R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-nicotine | CHEMBL440464 | Nicotin | US8609708, 54 Nicotine | Nikotin | Nicotine-(+) | 3-(1-methylpyrrolidin-2-yl)pyridine | US9284322, Nicotine | US9993465, Nicotine | US11667638, Example Nicotine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[N@@]1CCC[C@H]1c2cccnc2
Structure:
Search PDB for entries with ligand similarity: