Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma [258-518]
Ligand
BDBM221243
Substrate
n/a
Meas. Tech.
ThermoFluor® Assay
pH
7±n/a
Temperature
274.15±n/a K
Kd
4.1±n/a nM
Comments
extracted
Citation
 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent  US9303015 Publication Date 4/5/2016 
Target
Name:
Nuclear receptor ROR-gamma [258-518]
Synonyms:
NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat)
Type:
Enzyme
Mol. Mass.:
30146.98
Organism:
Homo sapiens (Human)
Description:
Artificial Sequence Construct used in the Thermofluor Assay (Seq No: 4)
Residue:
261
Sequence:
STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM221243
Synonyms:
US9303015, 17
Type:
Small organic molecule
Emp. Form.:
C28H26ClN5O3
Mol. Mass.:
515.991
SMILES:
COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(N(C)C)c(Oc3ccccc3)c(Cl)c2c1
Structure:
Search PDB for entries with ligand similarity: