Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM221915
Substrate
n/a
Meas. Tech.
GTPγS Binding Assay
pH
7.4±n/a
IC50
620±n/a nM
Citation
 Zhang, X; Wang, E; Guo, J; Niu, S; Dai, Z; Zheng, N; Ji, L; Wang, Z; Liang, T Heterocyclic group contained amino-methanol derivative, and salt, synthetic method and use thereof US Patent  US9315492 Publication Date 4/19/2016 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM221915
Synonyms:
US9315492, 12
Type:
Small organic molecule
Emp. Form.:
C18H17N5O4
Mol. Mass.:
367.3587
SMILES:
NC1(CO)CCc2cc(ccc2C1)-c1nc(no1)-c1ccnc(c1)[N+]([O-])=O
Structure:
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