Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM222228
Substrate
n/a
Meas. Tech.
HDAC2 Enzyme Assay
IC50
1.92e+3± 2.0e+2 nM
Citation
 Huong, TT; Dung, DT; Huan, NV; Cuong, LV; Hai, PT; Huong, LT; Kim, J; Kim, YG; Han, SB; Nam, NH Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. Bioorg Chem 71:160-169 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM222228
Synonyms:
N-Hydroxy-4-((4-((3-(hydroxyimino)-5-methoxy-2-oxoindolin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide (4f)
Type:
Small organic molecule
Emp. Form.:
C20H18N6O5
Mol. Mass.:
422.3941
SMILES:
COc1ccc2N(Cc3cn(Cc4ccc(cc4)C(=O)NO)nn3)C(=O)\C(=N/O)c2c1
Structure:
Search PDB for entries with ligand similarity: