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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM222286
Substrate
n/a
Meas. Tech.
α-Glucosidase Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
2.7456e+5± 9e+1 nM
Comments
extracted
Citation
 Chaudhry, F; Ather, AQ; Akhtar, MJ; Shaukat, A; Ashraf, M; Al-Rashida, M; Munawar, MA; Khan, MA Green synthesis, inhibition studies of yeast a-glucosidase and molecular docking of pyrazolylpyridazine amines. Bioorg Chem 71:170-180 (2017) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM222286
Synonyms:
N-(2,5-Dimethoxyphenyl)-6-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)pyridazin-3-amine (5l)
Type:
Small organic molecule
Emp. Form.:
C17H18N6O4
Mol. Mass.:
370.3626
SMILES:
COc1ccc(OC)c(Nc2ccc(nn2)-n2nc(C)c(c2C)[N+]([O-])=O)c1
Structure:
Search PDB for entries with ligand similarity: