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Target
Alpha-glucosidase MAL32
Ligand
BDBM223114
Substrate
n/a
Meas. Tech.
In Vitro α-Glucosidase Inhibitory Assay
pH
6.8±n/a
IC50
14090±160 nM
Comments
extracted
Citation
 Wang, G; Wang, J; He, D; Li, X; Li, J; Peng, Z Synthesis, in vitro evaluation and molecular docking studies of novel coumarin-isatin derivatives as a-glucosidase inhibitors. Chem Biol Drug Des 89:456-463 (2017) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL32
Synonyms:
Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase)
Type:
Hydrolase
Mol. Mass.:
68132.36
Organism:
Saccharomyces cerevisiae
Description:
Purchased from Wako Fine Chemicals Co. Ltd.
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM223114
Synonyms:
(Z)-N'-(1-benzyl-2-oxoindolin-3-ylidene)-2-((2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (5i)
Type:
Small organic molecule
Emp. Form.:
C26H19N3O5
Mol. Mass.:
453.4462
SMILES:
O=C(COc1ccc2ccc(=O)oc2c1)N\N=C1/C(=O)N(Cc2ccccc2)c2ccccc12
Structure:
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