Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50373349
Substrate
n/a
Meas. Tech.
Inhibition Kinetics Assay
pH
8±0
Temperature
298.15±0 K
Ki
158±0 nM
Citation
 Neckles, C; Eltschkner, S; Cummings, JE; Hirschbeck, M; Daryaee, F; Bommineni, GR; Zhang, Z; Spagnuolo, L; Yu, W; Davoodi, S; Slayden, RA; Kisker, C; Tonge, PJ Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry 56:1865-1878 (2017) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP reductase (FabI1)
Type:
Enzyme
Mol. Mass.:
27824.56
Organism:
Burkholderia pseudomallei
Description:
Q3JG55
Residue:
253
Sequence:
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTGNVEYIDGGYHVVG
  
Inhibitor
Name:
BDBM50373349
Synonyms:
CHEMBL264417 | PT12
Type:
Small organic molecule
Emp. Form.:
C18H21NO4
Mol. Mass.:
315.3636
SMILES:
CCCCCCc1ccc(Oc2ccc(cc2)[N+]([O-])=O)c(O)c1
Structure:
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