Reaction Details Report a problem with these data
Target
Caspase-5
Ligand
BDBM50240374
Substrate
n/a
Meas. Tech.
Caspase Catalytic Activity Assay
pH
7.4±n/a
IC50
8.7e+2± 9e+1 nM
Comments
extracted
Citation
 Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol 24:281-292 (2017) [PubMed]  Article 
Target
Name:
Caspase-5
Synonyms:
CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease
Type:
Enzyme
Mol. Mass.:
49760.80
Organism:
Homo sapiens (Human)
Description:
P51878
Residue:
434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
  
Inhibitor
Name:
BDBM50240374
Synonyms:
3-(4-biphenylylcarbonyl)propionic acid | 3-(4-phenylbenzoyl)propionic acid | 4-(4-biphenylyl)-4-oxobutyric acid | 4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 4-biphenyl-4-yl-4-oxobutanoic acid | CHEMBL277522 | Fenbufen | gamma-oxo(1,1'-biphenyl)-4-butanoic acid
Type:
Small organic molecule
Emp. Form.:
C16H14O3
Mol. Mass.:
254.2806
SMILES:
OC(=O)CCC(=O)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: