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Target
Caspase-5
Ligand
BDBM50233673
Substrate
n/a
Meas. Tech.
Caspase Catalytic Activity Assay
pH
7.4±n/a
IC50
5.9e+2± 8e+1 nM
Comments
extracted
Citation
 Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol 24:281-292 (2017) [PubMed]  Article 
Target
Name:
Caspase-5
Synonyms:
CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease
Type:
Enzyme
Mol. Mass.:
49760.80
Organism:
Homo sapiens (Human)
Description:
P51878
Residue:
434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
  
Inhibitor
Name:
BDBM50233673
Synonyms:
(+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-[4-(1-Oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-propionic acid | CHEMBL15870 | INDOPROFEN | cid_3718
Type:
Small organic molecule
Emp. Form.:
C17H15NO3
Mol. Mass.:
281.3059
SMILES:
CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
Structure:
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