Reaction Details Report a problem with these data
Target
Caspase-5
Ligand
BDBM223313
Substrate
n/a
Meas. Tech.
Caspase Catalytic Activity Assay
pH
7.4±n/a
IC50
4.7e+2± 3e+1 nM
Comments
extracted
Citation
 Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol 24:281-292 (2017) [PubMed]  Article 
Target
Name:
Caspase-5
Synonyms:
CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease
Type:
Enzyme
Mol. Mass.:
49760.80
Organism:
Homo sapiens (Human)
Description:
P51878
Residue:
434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
  
Inhibitor
Name:
BDBM223313
Synonyms:
Tiaprofenic acid
Type:
Small organic molecule
Emp. Form.:
C14H12O3S
Mol. Mass.:
260.308
SMILES:
CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1
Structure:
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