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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM223521
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<100±n/a nM
Citation
 Ahn, JH; Pagire, HS; Rhee, SD; Kim, KY; Jung, WH; Bae, M; Song, JS; Kim, K; Kwak, HJ Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient US Patent  US9321728 Publication Date 4/26/2016 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM223521
Synonyms:
US9321728, 75
Type:
Small organic molecule
Emp. Form.:
C32H36N2O4
Mol. Mass.:
512.6392
SMILES:
Cc1cccc(C)c1-c1ccc(cc1)C(=O)NCCC(=O)Nc1ccc(cc1)C1CC[C@H](CC(O)=O)CC1 |r,wD:31.34,$;;;;;;;;;;;;;;;;HN;;;;;HN;;;;;;;;;;;;;;;;$,(-9.34,5.01,;-10.67,4.24,;-12,5.01,;-13.34,4.24,;-13.34,2.7,;-12,1.93,;-12,.39,;-10.67,2.7,;-9.34,1.93,;-8,2.7,;-6.67,1.93,;-6.67,.39,;-8,-.39,;-9.34,.39,;-5.33,-.39,;-5.33,-1.93,;-4,.39,;-2.67,-.39,;-1.33,.39,;,-.39,;,-1.93,;1.33,.39,;2.67,-.39,;2.67,-1.93,;4,-2.7,;5.33,-1.93,;5.33,-.39,;4,.39,;6.67,-2.7,;8,-1.93,;9.34,-2.7,;9.34,-4.24,;10.67,-5.01,;12,-4.24,;13.34,-5.01,;12,-2.7,;8,-5.01,;6.67,-4.24,)|
Structure:
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