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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM223526
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<50±n/a nM
Citation
 Ahn, JH; Pagire, HS; Rhee, SD; Kim, KY; Jung, WH; Bae, M; Song, JS; Kim, K; Kwak, HJ Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient US Patent  US9321728 Publication Date 4/26/2016 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM223526
Synonyms:
US9321728, 94
Type:
Small organic molecule
Emp. Form.:
C30H31ClN2O4
Mol. Mass.:
519.031
SMILES:
OC(=O)C[C@H]1CCC(CC1)c1ccc(NC(=O)CCNC(=O)c2ccc(c(Cl)c2)-c2ccccc2)cc1 |r,wD:4.3,$;;;;;;;;;;;;;;HN;;;;;HN;;;;;;;;;;;;;;;;;$,(13.34,-5,;12,-4.23,;12,-2.69,;10.67,-5,;9.34,-4.23,;9.34,-2.69,;8,-1.93,;6.67,-2.69,;6.67,-4.23,;8,-5,;5.33,-1.93,;4,-2.69,;2.67,-1.93,;2.67,-.38,;1.33,.38,;,-.38,;,-1.93,;-1.33,.38,;-2.67,-.38,;-4,.38,;-5.33,-.38,;-5.33,-1.93,;-6.67,.38,;-6.67,1.93,;-8,2.69,;-9.34,1.93,;-9.34,.38,;-10.67,-.38,;-8,-.38,;-10.67,2.69,;-10.67,4.23,;-12,5,;-13.34,4.23,;-13.34,2.69,;-12,1.93,;4,.38,;5.33,-.38,)|
Structure:
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