Reaction Details Report a problem with these data
Target
DNA helicase [35-727]
Ligand
BDBM21690
Substrate
n/a
Meas. Tech.
DNA-Dependent ATPase Assay
pH
8±0
Temperature
310.15±0 K
IC50
9.9e+3±n/a nM
Citation
 Tarique, M; Tabassum, F; Ahmad, M; Tuteja, R Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth. BMC Biochem 15:9 (2014) [PubMed]  Article 
Target
Name:
DNA helicase [35-727]
Synonyms:
UvrD helicase (PfUDN)
Type:
Enzyme
Mol. Mass.:
81959.48
Organism:
Plasmodium falciparum
Description:
N-terminal fragment of P. falciparum UvrD helicase (35-727 aa)
Residue:
693
Sequence:
NFSEEQQRIIEIPMNVNLCIIACPGSGKTSTLTARIIKSIIEEKQSIVCITFTNYAASDLKDKIMKKINCLIDICVDNKINQKLFNNKNNKINFSLKNKCTLNNKMNKSIFKVLNTVMFIGTIHSFCRYILYKYKGTFKILTDFINTNIIKLAFNNFYSSMMSKTKGTQPGFSTILERKSNKASTQNCDPDKINTHNNDDNINNKNDYINNKNKNDYNNINNYDNINNYDNINNDDNINNDDNINNDDNINNDDNINNDDDINNCGNCNQPKGIPSQLAYFINCMKNAEIKEDEEKEFYEEEHDIQNDILNNDDNNNDEDDDDDDEFYNYLYNFKHSYEQTNDYFANEQVQSVLKKKNIIFLKKKIKLMKYIELYNIKIEINDVEKMFYEEYKKIFKKAKNIYYDFDDLLIETYRLMKDNADIRNKILEEWNYVFCDEFQDTNTTQFNILQFFVNHNVPSTLDQSIYTSGNLENKDIKDNHNISMSTYKSKQYSHSVQNFFNEHKVDQQLCDQIYFDKHCNNILMQNKNQQATHKHSEEEEEQEEEKKKNKKTKKTNTFINQQKIKTQTVLSYKQDEMSSSASSTYSYVKIEKEKKKYALNKIDDTYYNKKNIYSNNDEILDIENEQTFFNNNCNEKNKTKKKCNLKDRSLTVIGDDDQSIYSFRGAHINVFYKFLKDCNCLLFKLNNNFRST
  
Inhibitor
Name:
BDBM21690
Synonyms:
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid | 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid | Bay 09867 | CHEMBL8 | Ciprinol | Cipro | Ciprofloxacin | US11590142, Compound Ciprofloxacin | US9138393, Ciprofloxacin HCl | US9144538, Ciprofloxacin HCl
Type:
Small organic molecule
Emp. Form.:
C17H18FN3O3
Mol. Mass.:
331.3415
SMILES:
OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
Structure:
Search PDB for entries with ligand similarity: