Reaction Details Report a problem with these data
Target
DNA helicase [35-727]
Ligand
BDBM50370548
Substrate
n/a
Meas. Tech.
DNA-Dependent ATPase Assay
pH
8±0
Temperature
310.15±0 K
IC50
3.3e+3±n/a nM
Citation
 Tarique, M; Tabassum, F; Ahmad, M; Tuteja, R Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth. BMC Biochem 15:9 (2014) [PubMed]  Article 
Target
Name:
DNA helicase [35-727]
Synonyms:
UvrD helicase (PfUDN)
Type:
Enzyme
Mol. Mass.:
81959.48
Organism:
Plasmodium falciparum
Description:
N-terminal fragment of P. falciparum UvrD helicase (35-727 aa)
Residue:
693
Sequence:
NFSEEQQRIIEIPMNVNLCIIACPGSGKTSTLTARIIKSIIEEKQSIVCITFTNYAASDLKDKIMKKINCLIDICVDNKINQKLFNNKNNKINFSLKNKCTLNNKMNKSIFKVLNTVMFIGTIHSFCRYILYKYKGTFKILTDFINTNIIKLAFNNFYSSMMSKTKGTQPGFSTILERKSNKASTQNCDPDKINTHNNDDNINNKNDYINNKNKNDYNNINNYDNINNYDNINNDDNINNDDNINNDDNINNDDNINNDDDINNCGNCNQPKGIPSQLAYFINCMKNAEIKEDEEKEFYEEEHDIQNDILNNDDNNNDEDDDDDDEFYNYLYNFKHSYEQTNDYFANEQVQSVLKKKNIIFLKKKIKLMKYIELYNIKIEINDVEKMFYEEYKKIFKKAKNIYYDFDDLLIETYRLMKDNADIRNKILEEWNYVFCDEFQDTNTTQFNILQFFVNHNVPSTLDQSIYTSGNLENKDIKDNHNISMSTYKSKQYSHSVQNFFNEHKVDQQLCDQIYFDKHCNNILMQNKNQQATHKHSEEEEEQEEEKKKNKKTKKTNTFINQQKIKTQTVLSYKQDEMSSSASSTYSYVKIEKEKKKYALNKIDDTYYNKKNIYSNNDEILDIENEQTFFNNNCNEKNKTKKKCNLKDRSLTVIGDDDQSIYSFRGAHINVFYKFLKDCNCLLFKLNNNFRST
  
Inhibitor
Name:
BDBM50370548
Synonyms:
NOGALAMYCIN
Type:
Small organic molecule
Emp. Form.:
C39H49NO16
Mol. Mass.:
787.8035
SMILES:
CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@](C)(O)[C@H](C(=O)OC)c3cc4C(=O)c5c6O[C@@H]7O[C@@](C)([C@H](O)[C@H]([C@@H]7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)[C@H](OC)[C@]1(C)OC |r|
Structure:
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