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Target
Heat shock protein HSP 90-alpha [1-236]
Ligand
BDBM227589
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
7.5±0
Temperature
288.15±0 K
Kd
46.3±7.2 nM
Citation
 Tso, SC; Qi, X; Gui, WJ; Wu, CY; Chuang, JL; Wernstedt-Asterholm, I; Morlock, LK; Owens, KR; Scherer, PE; Williams, NS; Tambar, UK; Wynn, RM; Chuang, DT Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket. J Biol Chem 289:4432-43 (2014) [PubMed]  Article 
Target
Name:
Heat shock protein HSP 90-alpha [1-236]
Synonyms:
HS90A_HUMAN | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat-shock protein 90 (Hsp90)
Type:
Enzyme
Mol. Mass.:
26556.38
Organism:
Homo sapiens (Human)
Description:
Human Hsp90 (1-236 aa)
Residue:
236
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE
  
Inhibitor
Name:
BDBM227589
Synonyms:
Radicicol
Type:
Small organic molecule
Emp. Form.:
C18H17ClO6
Mol. Mass.:
364.777
SMILES:
C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |r,c:7,t:9|
Structure:
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