Reaction Details Report a problem with these data
Target
Androgen receptor [646-919]
Ligand
BDBM227647
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
6.5±n/a
Kd
2.8e+3± 1.6e+3 nM
Comments
extracted
Citation
 Jehle, K; Cato, L; Neeb, A; Muhle-Goll, C; Jung, N; Smith, EW; Buzon, V; Carbó, LR; Estébanez-Perpiñá, E; Schmitz, K; Fruk, L; Luy, B; Chen, Y; Cox, MB; Bräse, S; Brown, M; Cato, AC Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem 289:8839-51 (2014) [PubMed]  Article 
Target
Name:
Androgen receptor [646-919]
Synonyms:
ANDR_HUMAN | AR | Androgen receptor ligand-binding domain (AR-LBD) | DHTR | NR3C4
Type:
Protein
Mol. Mass.:
31698.13
Organism:
Homo sapiens (Human)
Description:
Human AR hinge-LBD (646-919 aa)
Residue:
274
Sequence:
ASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
  
Inhibitor
Name:
BDBM227647
Synonyms:
HDSKGQTKLLQLLTTKSDQM | SCR-2 peptide
Type:
Small organic molecule
Emp. Form.:
C96H166N28O33S
Mol. Mass.:
2272.578
SMILES:
CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(O)=O |r|
Structure:
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