Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM228616
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.8±n/a
IC50
890000±0 nM
Comments
extracted
Citation
 Lee, J; Yin, F; Bogyo, MS; Edgington, LE Specific inhibitors and active site probes for legumain US Patent  US9345789 Publication Date 5/24/2016 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM228616
Synonyms:
US9345789, LI-1
Type:
Small organic molecule
Emp. Form.:
C15H22N4O7
Mol. Mass.:
370.3578
SMILES:
CCOC(=O)[C@@H]1O[C@H]1C(=O)N(CC(N)=O)NC(=O)C1CCCN1C(C)=O |r|
Structure:
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