Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase PRDM9 [195-385]
Ligand
BDBM228649
Substrate
n/a
Meas. Tech.
Radioactivity-Based Assay
pH
8.5±n/a
Temperature
296.15±n/a K
Kd
1.2e+4±n/a nM
Comments
extracted
Citation
 Eram, MS; Bustos, SP; Lima-Fernandes, E; Siarheyeva, A; Senisterra, G; Hajian, T; Chau, I; Duan, S; Wu, H; Dombrovski, L; Schapira, M; Arrowsmith, CH; Vedadi, M Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. J Biol Chem 289:12177-88 (2014) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase PRDM9 [195-385]
Synonyms:
PFM6 | PR domain-containing protein 9 (PRDM9) | PRDM9 | PRDM9_HUMAN
Type:
Protein
Mol. Mass.:
21772.09
Organism:
Homo sapiens (Human)
Description:
Human PRDM9 truncation (195-385 aa)
Residue:
191
Sequence:
SEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANNGYSWLITKGRNCYEYVDGKDKSWANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWYGDEYGQELGIKWGSKWKKELMAGREPKP
  
Inhibitor
Name:
BDBM228649
Synonyms:
H3 (1-25) K4me3 | MARTKQTARKSTGGKAPRKQLATKA
Type:
Small organic molecule
Emp. Form.:
C115H212N41O33S
Mol. Mass.:
2729.233
SMILES:
CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r|
Structure:
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