Reaction Details
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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Ligand
BDBM228813
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
8±n/a
Kd
2.1e+3± 2e+2 nM
Comments
extracted
Citation
Jenkins, RJ; Heslip, KA; Meagher, JL; Stuckey, JA; Dotson, GD Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. J Biol Chem 289:15527-35 (2014) [PubMed] Article More Info.:
Target
Name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Synonyms:
LPXA_ECOLI | UDP-N-acetylglucosamine acryltransferase (LpxA) | lpxA
Type:
Enzyme
Mol. Mass.:
28083.70
Organism:
Escherichia coli (Enterobacteria)
Description:
P0A722
Residue:
262
Sequence:
MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR
Inhibitor
Name:
BDBM228813
Synonyms:
RJPXD33Δ6-COOH | TNLYML-COOH
Type:
Small organic molecule
Emp. Form.:
C34H55N7O10S
Mol. Mass.:
753.906
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
