Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM230659
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
20000±n/a nM
Comments
extracted
Citation
 Blaskovich, MA; Cassidy, PJ Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor US Patent  US9340517 Publication Date 5/17/2016 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM230659
Synonyms:
US9340517, 348
Type:
Small organic molecule
Emp. Form.:
C28H43ClN4O2
Mol. Mass.:
503.12
SMILES:
CCC(CC)CN1CC[C@H](CNC(=O)\C=C\c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O
Structure:
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