Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM190653
Substrate
n/a
Meas. Tech.
Inhibition Kinetics Assay
pH
7.5±n/a
Ki
11.0±0.4 nM
Comments
extracted
Citation
 Schiebel, J; Chang, A; Shah, S; Lu, Y; Liu, L; Pan, P; Hirschbeck, MW; Tareilus, M; Eltschkner, S; Yu, W; Cummings, JE; Knudson, SE; Bommineni, GR; Walker, SG; Slayden, RA; Sotriffer, CA; Tonge, PJ; Kisker, C Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem 289:15987-6005 (2014) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI
Type:
Enzyme
Mol. Mass.:
28019.03
Organism:
Staphylococcus aureus
Description:
Q2FZQ3
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM190653
Synonyms:
PT172
Type:
Small organic molecule
Emp. Form.:
C18H22ClNO
Mol. Mass.:
303.826
SMILES:
CCCCCCc1ccn(Cc2ccccc2Cl)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: