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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM190661
Substrate
n/a
Meas. Tech.
Inhibition Kinetics Assay
pH
7.5±n/a
Ki
7.0±0.1 nM
Comments
extracted
Citation
 Schiebel, J; Chang, A; Shah, S; Lu, Y; Liu, L; Pan, P; Hirschbeck, MW; Tareilus, M; Eltschkner, S; Yu, W; Cummings, JE; Knudson, SE; Bommineni, GR; Walker, SG; Slayden, RA; Sotriffer, CA; Tonge, PJ; Kisker, C Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem 289:15987-6005 (2014) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM190661
Synonyms:
PT166
Type:
Small organic molecule
Emp. Form.:
C19H25NO2
Mol. Mass.:
299.4073
SMILES:
CCCCCCc1cc(=O)c(Oc2ccccc2C)cn1C
Structure:
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